Organic Carbamates: An Unique Linkage in Anticancer Drug Design

Organic carbamates are the stable class of compounds derived from the unstable carbamic acid having O-CO-NHlinkage [1,2] with unique applications in the field of pharmaceuticals, agrochemicals (pesticides, herbicides, insecticides, fungicides etc.), intermediates in organic synthesis, in the forms of drugs and prodrugs, for the protection of amino groups in peptide chemistry, as a useful synthons, as linkers in combinatorial chemistry and also have interesting medicinal and biological properties [3]. In recent years, several reports have indicated that carbamate linkage present in between the active pharmacophores of various structurally diverse molecules increases manifold biological activities of semisynthetic/synthetic natural/synthetic molecules and proved to be a boon against various disease such as anti-cancer, anti-bacterial, anti-fungal, anti-malarial, anti-viral, anti-HIV, antiestrogenic, anti-progestational, anti-osteoporosis, antinflammatory, anti-filarial, anti-tubercular, anti-diabetic, anti-obesity, anticonvulsant, anti-helminthes, Alzheimer disease, CNS and CVS active etc. [4,5].